The Acute Coagulopathy of Trauma is Due to Impaired Initial Thrombin Generation but Not Clot Formation or Clot Strength
نویسندگان
چکیده
منابع مشابه
The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
BACKGROUND Acute coagulopathy of trauma (ACOT) has been described as a very early hypocoagulable state, but the mechanism remains controversial. One proposed mechanism is tissue hypoperfusion leading to protein C activation, with subsequent inhibition of Factors V and VIII. Variability in trauma has impeded the use of clinical data towards the elucidation of the mechanisms of ACOT, but thrombel...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2011
ISSN: 0022-4804
DOI: 10.1016/j.jss.2011.03.047